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Osteoarthritis (OA) is most prevalent of the chronic rheumatic diseases and is a leading cause of pain and disability. It is likely to increase in prevalence with aging population and higher rate of obesity. The conventional pharmacological treatment of OA with nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics often relieve symptoms however NSAIDs, in particular, cause serious side effects, including peptic ulcers and (less commonly) hepatic or renal failure. Glucosamine is a naturally occurring chemical and several clinical trials have shown that the supplementation with glucosamine is significantly associated with beneficial effects in patients with OA. Thus, glucosamine supplementation can play a vital role as safe and effective management in patients with OA.