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Osteoporosis is a serious public health problem which can lead to significant morbidity and mortality. It is essential to diagnose and treat this condition to prevent fragility fractures as they can cause severe disability and changes in the body. Several clinical studies have revealed that the supplementation with calcium, vitamin D, magnesium and zinc are associated with significant improvement in bone mass and also were reported to significantly reduce the bone turnover. Thus, treatment with these supplements plays a vital role in the prevention and treatment of osteoporosis.